Publication Date

2016

Document Type

Dissertation/Thesis

First Advisor

Majumdar, Pradip, 1954-

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Mechanical Engineering

LCSH

Nanostructured materials--Magnetic properties; Drug delivery systems; Biomedical materials; Chemotherapy

Abstract

The difference between success and failure of chemotherapy depends on not only on the drug itself but also how it is delivered to its target. In current research Magnetic Drug Targeting (MDT) plays an important role in effective drug delivery. Super para-magnetic Nano-particles filled with drug are used as a delivery system for anti-cancer agents in loco regional tumor therapy called magnetic drug targeting. The cancer loco regional tumors are identified and super paramagnetic particles are applied intra arterially close to the tumor region and focused to the tumor by a strong external magnetic field. With the injection of the magnetic drug particles in the blood stream, an external high-gradient magnetic field is applied in order to pull and create higher concentration concentrate at a specific target tumor site. In this study a three-dimensional computational simulation model for MDT is developed based on coupled blood flow dynamics and mass species transport in a blood flow artery network with externally applied magnetic field at the local target region. The main objective is to evaluate the effectiveness of the MDT method in delivering the drugs to the internal targeted tumor region. Further, the MDT method is optimized for the key process parameters such as particle size and the magnetic field parameters.

Comments

Advisors: Pradip Majumdar.||Committee members: kyu taek cho; venumadhav korampally.||Includes bibliographical references.||Includes illustrations.

Extent

ix, 61 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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