Publication Date
2019
Document Type
Dissertation/Thesis
First Advisor
Hosmane, Narayan S.
Degree Name
M.S. (Master of Science)
Legacy Department
Department of Chemistry and Biochemistry
Abstract
The functionalization of boron-based bioconjugates has long been studied for their potential use as a drug candidate for boron neutron capture therapy (BNCT). Also, magnetic nanoparticles have received greater attention due to their interesting magnetic properties and behaviors for selectively guiding them with an external magnetic field through the blood. A combination of the two ideas gives the framework for nanotechnology that has the potential to revolutionize drug delivery systems. This thesis will focus systematically on individual elements required for the many moving pieces required for magnetic drug targeting.
The research discussed in this thesis is divided into three parts. The first part investigates the synthesis and the encapsulation of iron oxide magnetite core nanoparticles and their characterization with a variety of spectroscopic techniques including, but not limited to, transmission electron microscopy (TEM), scanning transmission microscopy (SEM), electron energy loss spectroscopy (EELS), energy-dispersive x-ray spectroscopy (EDX), and Mössbauer spectroscopy (MS). The second part focuses on the synthesis, encapsulation, and characterization of boron nanoparticles core by pyrolysis of nido-decaborane (B10H14). The third part is an exploratory investigation on the synthesis of boron nitride nanotubes (BNNT) with an emphasis on the purification of the product to functionalize them for future boron-based bioconjugates for medical applications.
Recommended Citation
Wozny, John Ryan, "Nanomaterials of Iron Oxide, Boron, and Boron Nitride: on the Path to Magnetic Guided Bioconjugates for Medical Applications" (2019). Graduate Research Theses & Dissertations. 7790.
https://huskiecommons.lib.niu.edu/allgraduate-thesesdissertations/7790
Extent
131 pages
Language
eng
Publisher
Northern Illinois University
Rights Statement
In Copyright
Rights Statement 2
NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.
Media Type
Text
