Publication Date
12-4-2025
Document Type
Student Project
First Advisor
Isabel, Jeanne
Degree Name
B.S. (Bachelor of Science)
Department
Other
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive enzyme disorder affecting over 400 million people worldwide.G6PD is essential for producing NADPH, which maintains reduced glutathione (GSH)—the RBC’s primary defense against oxidative damage. When G6PD activity is low, RBCs cannot neutralize oxidants, leading to hemoglobin oxidation, Heinz body formation, and subsequent bite cells and hemolysis. Symptoms range from asymptomatic to acute hemolytic crises, especially after exposure to oxidative triggers such as infections, certain drugs, or fava beans.
Recommended Citation
Osias Arredondo, Annette C., "G6PD Deficiency" (2025). Honors Capstones. 1587.
https://huskiecommons.lib.niu.edu/studentengagement-honorscapstones/1587
