Author

L. Zuidema

Publication Date

4-24-2017

Document Type

Dissertation/Thesis

First Advisor

Hosmane, Narayan S., 1948-

Degree Name

B.S. (Bachelor of Science)

Department

Department of Chemistry and Biochemistry

Abstract

With a series of reactions, biological molecules Dopamine and L-Dopa were conjugated with carborane in an effort to synthesize new boron delivery agents for a bimodal cancer treatment known as Boron Neutron Capture Therapy (BNCT). The products of these reactions were purified using column chromatography, and characterized with Fourier-Transform Infrared Spectroscopy (FT-IR) and Nuclear Magnetic Resonance (NMR) Spectroscopy. The successful synthesis of carborane-appended dopamine and L-Dopa has been supported with characterizations performed thus far. In the future, the compounds will undergo further analysis with elemental analysis, mass spectroscopy, and biodistribution studies to determine cytotoxicity and cellular uptake in the future.

Extent

21 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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