Publication Date
4-24-2017
Document Type
Dissertation/Thesis
First Advisor
Hosmane, Narayan S., 1948-
Degree Name
B.S. (Bachelor of Science)
Legacy Department
Department of Chemistry and Biochemistry
Abstract
With a series of reactions, biological molecules Dopamine and L-Dopa were conjugated with carborane in an effort to synthesize new boron delivery agents for a bimodal cancer treatment known as Boron Neutron Capture Therapy (BNCT). The products of these reactions were purified using column chromatography, and characterized with Fourier-Transform Infrared Spectroscopy (FT-IR) and Nuclear Magnetic Resonance (NMR) Spectroscopy. The successful synthesis of carborane-appended dopamine and L-Dopa has been supported with characterizations performed thus far. In the future, the compounds will undergo further analysis with elemental analysis, mass spectroscopy, and biodistribution studies to determine cytotoxicity and cellular uptake in the future.
Recommended Citation
Zuidema, L., "The Synthesis of Carborane-Appended Dopamine and L-Dopa for Boron Neutron Capture Therapy" (2017). Honors Capstones. 1295.
https://huskiecommons.lib.niu.edu/studentengagement-honorscapstones/1295
Extent
21 pages
Language
eng
Publisher
Northern Illinois University
Rights Statement
In Copyright
Rights Statement 2
NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.
Media Type
Text
