B.S. (Bachelor of Science)
School of Nursing and Health Studies
The effect of ethanol administration on plasma levels of growth hormone (GH) and somatomedin C (IGF-1) was investigated on 26-day-old male and female rats. Ethanol (3gm/kg) was administered IP to 5 male and 5 female rats at ages 24 and 25 days. Saline (10 ml/kg) was administered to 5 male and 5 female control rats on the same days. At age 26 days blood was collected by cardiac puncture at sacrifice. IGF-1 was extracted using C-18 cartridges, and plasma concentrations of GH and IGF-1 levels in ethanol groups compared to the control groups. Lowered plasma levels of IGF-1 may be a result of variables in the extraction methods. It is possible that ethanol reduces plasma levels of GH and somatomedins, which may have a role in mediating growth retardation associated with ethanol exposure conditions such as fetal alcohol syndrome.
Suriano, Mary Jean, "The role of somatomedin in mediating ethanol induced growth retardation with potential impact on nursing practice related to fetal alcohol syndrome" (1989). Honors Capstones. 1279.
Northern Illinois University
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