Publication Date

1-1-1989

Document Type

Dissertation/Thesis

First Advisor

Frerichs, Marian

Degree Name

B.S. (Bachelor of Science)

Legacy Department

School of Nursing and Health Studies

Abstract

The effect of ethanol administration on plasma levels of growth hormone (GH) and somatomedin C (IGF-1) was investigated on 26-day-old male and female rats. Ethanol (3gm/kg) was administered IP to 5 male and 5 female rats at ages 24 and 25 days. Saline (10 ml/kg) was administered to 5 male and 5 female control rats on the same days. At age 26 days blood was collected by cardiac puncture at sacrifice. IGF-1 was extracted using C-18 cartridges, and plasma concentrations of GH and IGF-1 levels in ethanol groups compared to the control groups. Lowered plasma levels of IGF-1 may be a result of variables in the extraction methods. It is possible that ethanol reduces plasma levels of GH and somatomedins, which may have a role in mediating growth retardation associated with ethanol exposure conditions such as fetal alcohol syndrome.

Comments

Includes bibliographical references.

Extent

18 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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