M.S. (Master of Science)
Department of Electrical Engineering
Affordable and easy to use biological assays are the current need of the day owing to the rising cost of health care within the US and worldwide. The goal of this thesis is to develop a sensitive label-free biosensing scheme exploiting surface plasmon resonance (SPR) that yields the sensor output in an easy-to-read optical bio-barcode format for high through put and multiplexed medical diagnostics. Through this research, we would like to investigate if SPR phenomena can be achieved by fabricating SP supporting metallic structures over a nanoporous dielectric layer whose optical constants are progressively varied across the substrate in a bar code format. The optical properties of plasmonic materials are defined by the propagating surface plasmon resonance excited in thin metallic films. The sensor architecture of the proposed biosensor comprises of a metal film (Ag) deposited over a nano porous dielectric layer (NPO); whose refractive indices are gradually varied across the substrate in a bar code format. A fluorescent film is then deposited over the metal. The intensity of the fluorescence emission depends upon the strength of the SPR modes thus producing a bar code of electrical field intensities. The surface plasmon resonance peak position is dependent on the polymer films composition, substrate temperature and silver layer thickness. The proposed sensors can be developed as simple dipsticks and are being intended for use in bed-side diagnostics (commercial applications) and diagnostics for resource poor locations.
Ramesh, Sneha, "Barcode Biosensors Based on Surface Plasmon Resonance" (2021). Graduate Research Theses & Dissertations. 7579.
Northern Illinois University
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