Publication Date

2020

Document Type

Dissertation/Thesis

First Advisor

Vahabzadeh, Sahar

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Mechanical Engineering

Abstract

Titanium is one of the most attractive metal used in orthopedic and drug delivery applications because of its excellent mechanical properties, biocompatibility and high corrosion resistance. However, due to its bio-inertness, fibrous tissue forms between the bone and implant which causes loosening of implant. Surface modification can play an important role to enhance interaction between implant and the surrounding tissues which reduces the implant failure. The aim of this study is to a) incorporate magnesium (Mg) into modified titanium surface by different deposition methods for bone-implant interaction, b) modify the surface of titanium by alkali treatment, and c) investigate the release behavior of aloe-emodin (AE) from surface modified titanium substrate.

Different deposition methods were used to investigate the doping of magnesium content on titanium modified surface. Our result showed that the magnesium content on titanium modified surface enhanced with the increase of magnesium precursor concentration in the deposition solution. Alkali treatment was performed using different concentrations of NaOH, temperatures and rotation of speeds and we found these parameters affect formation of web-like or nearly web-like structures on polished titanium samples. Release behavior of AE from modified Ti samples was controlled by applying PLGA coating at different PLA:PGA ratio and increase in osteoblast cell adhesion and proliferation was found in polymer coated samples.

In conclusion, current research investigated various routes to modify the surface of Ti for drug delivery and bone tissue engineering application.

Extent

90 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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