Publication Date

2015

Document Type

Dissertation/Thesis

First Advisor

Majumdar, Pradip, 1954-

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Mechanical Engineering

LCSH

Mechanical engineering; Liver--Tumors--Treatment--Research; Cancer--Treatment--Research; ELF electromagnetic fields--Physiological effect--Research; ELF electromagnetic fields--Health aspects--Research

Abstract

Hepatic tumors occur in liver tissue due to the growth of malignant cells. Low Frequency Joule Heating (LFJH) is one of the cancer treatment methods that show tremendous potential to treat hepatic cancer without causing excessive side effects and patience discomfort as other cancer treatments such as chemotherapy. In this localized thermal treatment method the tumor in liver tissue is heated to a critical temperature range using Radiofrequency (RF) energy designed to damage malignant cells. An electrode is introduced over the tumor and electric current is passed through it to induce Joule heating. The volume heat generation due to the Joule heating raises local temperature in tumor cells and causes complete destruction or damage. In this study, a computational simulation model is created based on coupled solution of Bioheat equation and Electrical field equation, and considering a composite region of malignant tumor embedded in liver tissue region. The electrical and thermal fields that can cause damage to the malignant cells without affecting the surrounding tissue are determined and optimized by changing various controlling parameters such as electrode design, frequency and amplitude of the RF energy.

Comments

Advisors: Pradip Majumdar.||Committee members: Kyu Taek Cho; Greg Zhang.

Extent

72 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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