Publication Date

2015

Document Type

Dissertation/Thesis

First Advisor

Hosmane, Narayan S., 1948-

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Chemistry and Biochemistry

LCSH

Chemistry; Biomolecules--Synthesis--Research; Carboranes--Synthesis--Research; Organoboron compounds--Synthesis--Research

Abstract

A multi-step organic synthetic methodology to attach multiple boron-containing carborane cages (boron source) to suitable biocompatible organic compounds (carriers) that can be used for boron neutron capture therapy (BNCT) applications has been established1. The method involves alkylation of the selected organic compounds followed by conjugation with a polyhedral carborane cage using a click reaction2, 3(see scheme 1). To date, carborane derivatives of 4-nitroimidazole, 2-nitroimidazole, phenothiazine, 1, 3, 4-thiadiazole-2, 5-dithiol, adenine, 6-chloropurine and 3', 5'-dihydroxyacetophenone have been successfully synthesized. In addition, different coumarin derivatives were successfully synthesized using click chemistry. All products were purified and isolated in good yields and characterized using Fourier-Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), elemental analysis and Mass Spectrometry (MS). These products could be made water soluble by decapitation of the carborane cage in order for their biological evaluation.

Comments

Advisors: Narayan S. Hosmane.||Committee members: Timothy J. Hagen; Lee S. Sunderlin.

Extent

129 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

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