Kresheck, Gordon C.
M.S. (Master of Science)
Department of Chemistry
Phosphine; Phospholipids; Phase partition; Organophosphorus compounds
A series of dimethylalkylphosphine oxides containing the octyl, decyl and dodecyl alkyl group were synthesized and characterized according to the procedure of Hays. These compounds behave as nonionic surfactants in an aqueous solution with complex phase diagrams. We have determined the cloud points for several mixtures containing both synthetic and biological phospholipids. Some of the resulting solutions exhibited relative viscosities which were greater than 80% aqueous glycerol indicating the presence of very asymetric mixed micelles as previously reported for micelles containing dimyristoyl phosphatidylcholine and dimethyldecylphosphine oxide. The potential use of these compounds during the isolation of membrane proteins will be discussed.
Hwang, Jaiweon, "Phase separation properties of several aqueous alkyl phosphine oxide-phospholipid mixtures" (1990). Graduate Research Theses & Dissertations. 4365.
v, 57 pages
Northern Illinois University
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Includes bibliographical references (pages -49)