Roger Diveley

Publication Date

1993

Document Type

Dissertation/Thesis

First Advisor

Mitchell, John L. A.

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Biological Sciences

LCSH

Polyamines; Biological control systems; Mammals--Cytology

Abstract

Polyamines are small, highly abundant organic cations that are found in all living cells. Internal polyamine concentrations in mammalian cells are under strict regulation. The main contributors to cellular polyamine levels are: a) de novo production via ornithine decarboxylase, and b) uptake from the extracellular fluids by active transport. Both of these processes are precisely regulated by feedback controls. Recent studies have begun to demonstrate the control of polyamine biosynthesis; however, the mechanism of regulation of the transporter was unknown until this study. The work described in this thesis demonstrates that the feedback regulation of the polyamine transporter is via a spermidine-induced labile protein.

Comments

Includes bibliographical references (pages [39]-42)

Extent

42 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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