Publication Date

1984

Document Type

Dissertation/Thesis

First Advisor

King, Sondra L.

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Home Economics

LCSH

Calcium metabolism; Diabetes

Abstract

Plasma and bone calcium levels were measured in both alloxan diabetic and Ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) treated rats. The investigation was based on the hypothesis that both diabetes and treatment with EHDP inhibits the l-α hydroxylase enzyme necessary for the conversion of 25-OH D2 to 1,25 (OH)2 D3. This may alter calcium metabolism and normal bone mineralization in rats. Plasma calcium levels were unaltered in all groups (control, uncontrolled diabetic, controlled diabetic, and EHDP treated) indicating that the non-overnight fasted rat can maintain calcium homeostasis regardless of the treatment status. Uncontrolled diabetes and treatment with EHDP showed parallel results with a decrease in bone mass and an increase in bone calcium concentration. These findings show that diabetes and EHDP may be inhibiting 1,25 (OH)2 D3 action on resorption of bone, and the bones are losing mineral mass other than calcium. Whether the lost mineral is phosphorus or some other mineral is not known. Our study indicates a similarity in physiochemical action for uncontrolled diabetes and treatment with EHDP on altering bone metabolism in the rat.

Comments

Bibliography: pages 40-42.

Extent

v, 42 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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