Publication Date
1984
Document Type
Dissertation/Thesis
First Advisor
King, Sondra L.
Degree Name
M.S. (Master of Science)
Legacy Department
Department of Human and Family Resources
LCSH
Diabetes--Complications; Blood cholesterol; Thyroid hormones
Abstract
The investigation was based on the hypothesis that both diabetes and treatment with EHDP inhibits 1 - αhydroxylase enzyme necessary for the conversion of 25-OH-D₂ to 1, 25 (0H)₂D₃ and lowering of 1, 25 (0H)₂D₃ may alter thyroid hormone levels. Plasma cholesterol was measured in both alloxan diabetic rates and Ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) treated rats; Plasma thyroxine (T₄) and 3, 5, 3'-triiodothyronine was measured in EHDP treated animals. Hypercholesterolemia resulted from untreated diabetes mellitus. Serum thyroxine levels were unaltered in EHDP treated groups and serum triiodothyronine levels were significantly higher in EHDP treated groups and serum triiodothyronine levels were significantly higher in EHDP treated group. No conclusions could be made from these results and more research is needed to further investigate the relationship between EHDP and thyroid hormone.
Recommended Citation
Kutty, Renuka, "A comparative study on the effects of Diabetes Mellitus and ethane-1-hydroxy-1, 1-diphosphonic acid on plasma cholesterol, plasma thyroxine and 3, 5, 3'-triiodothyronine in the rat" (1984). Graduate Research Theses & Dissertations. 134.
https://huskiecommons.lib.niu.edu/allgraduate-thesesdissertations/134
Extent
v, 34 pages
Language
eng
Publisher
Northern Illinois University
Rights Statement
In Copyright
Rights Statement 2
NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.
Media Type
Text
