Author ORCID Identifier
Michael Vega: https://orcid.org/0000-0002-5539-6394
Laurence Lurio: https://orcid.org/0000-0002-7861-3654
Elizabeth R. Gaillard: https://orcid.org/0000-0002-2791-7762
Document Type
Article
Publication Title
Physical Review E
Abstract
The dynamics of concentrated suspensions of the eye-lens protein alpha crystallin have been measured using x-ray photon correlation spectroscopy. Measurements were made at wave vectors corresponding to the first peak in the hard-sphere structure factor and volume fractions close to the critical volume fraction for the glass transition. Langevin dynamics simulations were also performed in parallel to the experiments. The intermediate scattering function f(q,τ) could be fit using a stretched exponential decay for both experiments and numerical simulations. The measured relaxation times show good agreement with simulations for polydisperse hard-sphere colloids.
First Page
020601-1
Last Page
020601-5
DOI
10.1103/PhysRevE.97.020601
Publication Date
2-18-2018
Recommended Citation
P. Vodnala, N. Karunaratne, L. Lurio, G.M. Thurston, M. Vega, E. Gaillard, S. Narayanan, A. Sandy, Q. Zhang, E.M. Dufresne, G. Foffi, P. Grybos, P. Kmon, P. Maj, and R. Szczygiel, Hard-sphere-like Dynamics in Highly Concentrated Alpha-crystallin Suspensions, Phys. Rev. E. 97, 020601 (2018).
Original Citation
P. Vodnala, N. Karunaratne, L. Lurio, G.M. Thurston, M. Vega, E. Gaillard, S. Narayanan, A. Sandy, Q. Zhang, E.M. Dufresne, G. Foffi, P. Grybos, P. Kmon, P. Maj, and R. Szczygiel, Hard-sphere-like Dynamics in Highly Concentrated Alpha-crystallin Suspensions, Phys. Rev. E. 97, 020601 (2018).
Department
Department of Biological Sciences| Department of Chemistry and Biochemistry| Department of Physics
Sponsorship
Research reported in this publication was supported by the National Eye Institute of the National Institutes of Health under Award No. R15EY018249. The content is solely the responsibility of the authors and does not necessarily reflect the official views of the National Institutes of Health. This research used resources of the Advanced Photon Source, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. UFXC32k detector development was supported by the National Center for Research and Development, Poland PBS1/A3/12/2012 in the years 2012–2016 and by the National Science Center, Poland, under Contract No. UMO-2016/21/B/ST7/02228. [1] W. van Megen, T. C. Mortensen, S. R. Williams, and J. Müller, Phys. Rev. E 58, 6073 (1998). [2] A. Robert, J. Wagner, W. Härtl, T. Autenrieth, and G. Grübel, Eur. Phys. J. E 25, 77 (2008). [3] P. N. Pusey, in Liquids Freezing and the Glass Transition, edited by J. P. Hansen, D. Levesque, and J. Zinn (Elsevier, Amsterdam, 1991) Book section10, pp. 763–942. [4] G. L. Hunter and E. R. Weeks, Rep. Prog. Phys. 75, 066501 (2012). [5] J. A. Dix andA. S. Verkman, Ann. Rev. Biophys. 37, 247 (2008). [6] A. Giannopoulou, A. J. Aletras, N. Pharmakakis, G. N. Papatheodorou, and S.N.Yannopoulos, J. Chem. Phys. 127, 205101 (2007). [7] H. Bloemendal, W. de Jong, R. Jaenicke, N. H. Lubsen, C. Slingsby, and A. Tardieu, Prog. Biophys. Mol. Biol. 86, 407 (2004). [8] G.Grübel, A. Madsen, and A. Robert, in Soft-MatterCharacterization, edited by R. Borsali and R. Pecora (Springer, Heidelberg, 2008), pp. 953–995 . [9] M. Sutton, C. R. Phys. 9, 657 (2008). [10] G. Foffi, G. Savin, S. Bucciarelli, N. Dorsaz, G. M. Thurston, A. Stradner, and P. Schurtenberger, Proc. Natl. Acad. Sci. USA 111, 16748 (2014). [11] W. Götze and L. Sjögren, Phys. Rev. A 43, 5442 (1991). [12] S. Bucciarelli, J. S. Myung, B. Farago, S. Das, G. A. Vliegenthart, O. Holderer, R. G. Winkler, P. Schurtenberger, G. Gompper, and A. Stradner, Sci. Adv. 2, e1601432 (2016). [13] W. Götze, Complex Dynamics of Glass-Forming Liquids: A Mode-Coupling Theory, International Series of Monographs on Physics (Oxford University Press, Oxford, 2008). [14] G. Thurston, J. Chem. Phys. 124, 134909 (2006). [15] J. Thomson and R. Augusteyn, Exp. Eye Res. 37, 367 (1983). [16] C. DeCaro, V. N. Karunaratne, S. Bera, L. B. Lurio,A. R. Sandy, S. Narayanan, M. Sutton, J. Winans, K. Duffin, J. Lehuta, and N. Karonis, J. Synchrotron Radiat. 20, 332 (2013). [17] Q. Zhang, E. M. Dufresne, P. Grybos, P. Kmon, P. Maj, S. Narayanan, G.
Rights Statement
©2018 American Physical Society
