Stafstrom, Joel P.
B.S. (Bachelor of Science)
Department of Biological Sciences
In all organisms studied to date there exists a highly conserved family of GTP- binding proteins known as Developmentally Regulated GTP-Binding (DRG) proteins. DRG genes are believed to function as part of a pathway that consists of at least three genes: DRG, DFRP and SLH Gene. The DRG protein is a GTPase with all five motifs which characterize GTP-binding proteins, G1-G5 (Li & Trueb, 2000). The DFRP protein forms a physical protein-protein interaction with DRG through its DFRP domain and prevents ubiquitination and degradation of the DRG protein (Ishikawa et al, 2005 & Isikawa et al, 2009). The SLH gene, a dead helicase box gene, also interacts with DRG through what is believed to be a genetic pathway; no evidence suggests that a physical protein-protein interaction occurs between these two molecules. Together DRG, DFRP, and SLH genes form a pathway which performs an unknown function.
Trout, Jared, "Phenotyping, genotyping, and analysis of arabidopsis : knockout mutations DFRP1, DFRP2 and SLH genes" (2013). Honors Capstones. 886.
Northern Illinois University
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