Author

Jared Trout

Publication Date

1-1-2013

Document Type

Dissertation/Thesis

First Advisor

Stafstrom, Joel P.

Degree Name

B.S. (Bachelor of Science)

Department

Department of Biological Sciences

Abstract

In all organisms studied to date there exists a highly conserved family of GTP- binding proteins known as Developmentally Regulated GTP-Binding (DRG) proteins. DRG genes are believed to function as part of a pathway that consists of at least three genes: DRG, DFRP and SLH Gene. The DRG protein is a GTPase with all five motifs which characterize GTP-binding proteins, G1-G5 (Li & Trueb, 2000). The DFRP protein forms a physical protein-protein interaction with DRG through its DFRP domain and prevents ubiquitination and degradation of the DRG protein (Ishikawa et al, 2005 & Isikawa et al, 2009). The SLH gene, a dead helicase box gene, also interacts with DRG through what is believed to be a genetic pathway; no evidence suggests that a physical protein-protein interaction occurs between these two molecules. Together DRG, DFRP, and SLH genes form a pathway which performs an unknown function.

Comments

Includes bibliographical references.

Extent

28 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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