Hagen, Timothy J.
B.S. (Bachelor of Science)
Department of Chemistry and Biochemistry
Numerous studies have shown that Hepatitis C virus (HCV) and Dengue virus (DENV) are from the same family and have many characteristics in common. Despite the similarities, no adequate vaccines or antivirals have been developed for DENV yet although many are commercially available for HCV. In this research, we investigated the relationship between HCV and DENV, especially their NS3/4A and NS2B/3 proteases, to aid in the development of antiviral against DENV. To achieve this, in-depth structural analyses of the complexes were conducted; and molecular modeling stimulation software were utilized to visualize the interactions of the enzymes with different potential inhibitors including a potent inhibitor, Aprotinin. All peptoids derived bound to the active site of the enzyme complex near the catalytic triad although the interactions were not as strong as those in Aprotinin itself. Nonetheless, they demonstrate a good potential to for targeting the NS2B/3 protease. Further optimizations include increasing the rigidity of the structure through cyclization and eliminating residues that do not participate in the interaction with the enzyme.
Cheng, Thimoro, "Investigation of Dengue Virus (DENV) NS2B/3 Protease for Antiviral Development" (2018). Honors Capstones. 695.
Northern Illinois University
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