Publication Date

1-1-1998

Document Type

Dissertation/Thesis

First Advisor

Yasui, Linda S.

Degree Name

B.S. (Bachelor of Science)

Department

Department of Biological Sciences

Abstract

Double strand breaks in cells may arise due to a number of reasons including mutagens and normal cellular processes such as V(D)J recombination. Unrepaired strand damage can result in broken chromosomes and cell death. Improper repair can lead to cancer. A specific component of nonhomologous recombination to repair DSBs was studied in two different cell lines, Chinese hamster ovary K1 cells and xrs cells. Xrs cells, deficient in Ku protein were impaired in their ability to repair DSBs induced by ionizing radiation. These results and other findings support the critical function of Ku in DSB repair and indicate a multiple roles of Ku in DNA metabolism.

Comments

Includes bibliographical references.

Extent

61 unnumbered pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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