Gasser, Kenneth W.
B.S. (Bachelor of Science)
Department of Biological Sciences
In this project, I have done extensive research on two chemotherapy regimens, cisplatin/5-fluorouracil and cisplatin/Adriamycin. My hope is to compare and contrast the effectiveness of cisplatin-based regimens in the treatment of head and neck squamous cell carcinomas, osteosarcomas of the jaw, and ovarian cancers. In addition to literature searches, I have studied the medical files of two patients who were treated with cisplatin. One patient had recurrent, unresectable head and neck cancer and one patient has a resected, metastatic osteosarcoma of the mandible. After studying the case of the patient with head and neck cancer, I found exceptional results. After only one cycle of cisplatin/5FU, CT and PET scans showed no evidence of disease. I have concluded that cisplatin was effective in this case. As for the case of the patient with an osteosarcoma of the mandible, he showed mixed responses to cisplatin/Adriamycin. However, his responses to this regimen are much improved compared with his responses to his initial chemotherapy with a furosemide regimen. While on furosemide, his disease became metastatic, spreading to his lungs. Finally, my research on cisplatin-based chemotherapy for the treatment of ovarian cancer showed that other anti-cancer drugs, like docetaxel, may be more effective.
Kersten, Tara, "Cisplatin-based chemotherapy for treatment of head and neck cancers, osteosarcomas of the jaw bone, and ovarian cancers" (2007). Honors Capstones. 294.
Northern Illinois University
Rights Statement 2