Publication Date

1-1-1988

Document Type

Dissertation/Thesis

Degree Name

B.S. (Bachelor of Science)

Department

Department of Chemistry and Biochemistry

Abstract

Methyl-4-oxo-10-(1-oxoethoxy)-tricyclo[6.3.0.0²,⁶]undecan-5-oate, a synthetic precursor to hirsutene, was prepared in moderate yields via an intramolecular radical tandem cyclization of 4-(2,6-cyclo-octadienyl)methyl acetoacetate induced by manganese (III) acetate. Two analogous polysubstituted dihydrofurans of expected PAF antagonistic activity were prepared in good yields from the manganese(III) acetate induced fusion of a substituted styrene with a substituted benzoyl acetate. The use of manganese(III) acetate oxidations in the syntheses of such diverse compounds promises greater applications of this chemistry towards other synthetic problems in the future.

Comments

Includes bibliographical references.

Extent

15 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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