Superelectrophilic nazarov cyclizations with N-heterocycles

Author ORCID Identifier

Harouna Amadou:https://orcid.org/0000-0001-8105-1384

Douglas Klumpp:https://orcid.org/0000-0001-5271-699X

Publication Title

Tetrahedron

ISSN

00404020

E-ISSN

44155

Document Type

Article

Abstract

A series of Nazarov cyclizations has been studied involving N-heterocyclic-substituted 1-arylprop-2-en-1-one derivatives (aza-chalcones). Superacid catalyzed reactions of these derivatives provide good yields of heterocyclic-substituted 1-indanones. A mechanism is proposed involving diprotonated, superelectrophilic intermediates.

Publication Date

11-20-2020

DOI

10.1016/j.tet.2020.131644

Keywords

Heterocycles, Indanone, Nazarov, Superacid, Superelectrophile

Department

Department of Chemistry and Biochemistry

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