Synthesis of Menthol Glycinates and Their Potential as Cooling Agents
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A convenient method of synthesis has been developed for a new class of potential cooling agents, menthol glycinates. These compounds are prepared in two synthetic steps, starting from bromoacetyl bromide and (-)-menthol. The resulting brominated menthol ester readily undergoes substitution reactions with NH3 and 1° or 2° amines to provide menthol glycinates. For most of the prepared compounds, the two-step synthetic procedure requires no aqueous phase extractions.
Klumpp, Douglas A.; Sobel, Robert M.; Kokkinidou, Smaro G.; Osei-Badu, Brian; Liveris, Zachary; Klumpp, Rachel A.; and Stentzel, Michael R., "Synthesis of Menthol Glycinates and Their Potential as Cooling Agents" (2020). NIU Bibliography. 301.
Department of Chemistry and Biochemistry