M.S. (Master of Science)
Department of Biology
Richert and Prahlad (1972b) demonstrated the effect of the organophosphate insecticide thimet on the thyroid fixation of the. chick. In this study the effect of aldrin and nabam on the thyroid function in the chick was examined. Also the effect of aldrin on the adrenal function was investigated. Fertile White Leghorn chicken eggs were injected on the tenth day of incubation with either 0, 10, 20, 30, 40, 50 parts per million (ppm) aldrin or 0, 5, 10, 15 ppm nabam and allowed to hatch. The following parameters were studied : hatchability, number of deformities induced, mortality up to the tenth day after hatching, relative thyroid weight, thyroid gland histology, 125I uptake by the thyroid gland, relative adrenal weight, corticosterone concentration of the adrenal gland, quantitative amounts of hormone in the thyroid gland, and 125I incorporation into the thyroid hormones. The effects of aldrin were minimal on the above parameters. All of the experimental groups were not significantly different, from the controls in the following: hatchability, deformities, relative thyroid weight, thyroid gland histology, relative adrenal weight, or corticosterone concentration. 125I uptake was significantly reduced in the 30, 40, and 50 ppm groups with the other groups showing a trend of decreased uptake. Both the 40 and 50 ppm chicks showed an increased number of mortalities through the tenth day after hatching. Thin layer chromatography (TLC) studies indicated that aldrin, at the highest dosage, may block the iodine trapping mechanism of the thyroid gland. Animals injected with nabam showed a lowered hatchability and increased thyroid weight compared to control animals. 10 and 15 ppm increased the number of deformities in the chicks that hatched. In addition 15 ppm increased the 125I uptake, significantly. Some animals in the 15 ppm group also required assistance in hatching. Thyroid hormone concentrations determined by TLC indicated that nabam might interfere with the coupling of iodotyrosines.
Kuzan, Frank B., "The effects of 1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4-endo,exo-5, 8-dimethano napthalene (aldrin) and sodium ethylenebisdithiocarbamate (nabam) on the chick" (1974). Graduate Research Theses & Dissertations. 5591.
Northern Illinois University
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