Publication Date

2016

Document Type

Dissertation/Thesis

First Advisor

Majumdar, Pradip, 1954-

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Mechanical Engineering

LCSH

Brain--Cancer--Treatment; Cerebral circulation; Brain--Blood-vessels--Imaging; Cerebrovascular disease--Diagnosis

Abstract

Brain is the most intricate organ of human body. The development of new therapeutic techniques for Brain tumor diseases is a difficult task, yet these treatments are not effective for almost all the brain diseases. Presence of Blood Brain Barrier (BBB) is the main challenge in development of drugs to treat brain diseases in most of the cases. Among several brain diseases, brain tumors often have poor prognosis, which depends and changes according to the type of the tumor. In this study a three-dimensional computational simulation model for analyzing multifunctional drug distribution through the cerebral artery and adjacent tissue region with tumor is considered. The simulation model includes solution of governing equations of blood flow dynamics based on Navier-Stokes equations and mass species transport based on Lagrangian particle flow dynamics in the artery network and capillaries of the adjacent tissue-tumor regions subjected to typical cardiac cycle. The main objective is to evaluate the effective delivery of selective drug particles to the targeted tumor region with variation in the selective multifunctional particle types and sizes.

Comments

Advisors: Pradip Majumdar.||Committee members: Amartya Chakrabarti; John Shelton.||Includes bibliographical references.||Includes illustrations.

Extent

ix, 35 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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