Publication Date


Document Type


First Advisor

Lints, Carlton E.

Degree Name

M.A. (Master of Arts)

Legacy Department

Department of Psychology


Noradrenaline; Serotonin; Spasms; Brain chemistry


Numerous pharmacological studies have suggested that brain norepinephrine (NE) and serotonin (5-HT) are inhibitory with respect to audiogenic seizures. Also, it has been suggested that mice genetically prone to audiogenic seizures may have a deficit in the functioning of one or both of these transmitter systems. The studies comparing the brain levels of NE and 5-HT in seizure prone and seizure resistant mice have thus far produced contradictory results. This study was undertaken to compare the endogenous levels as well as the turnover of NE and 5-HT in six discrete regions of the brains of seizure prone (DBA) and seizure resistant (C57) strains of mice at their age of peak seizure susceptibility. The brains were dissected into cerebellum, hindbrain (included pons and medulla), inferior colliculus, superior colliculus, diencephalon (included thalamus and hypothalamus), and telencephalon. Although no significant differences between the two strains were found in the levels or turnover of these amines in the six regions studied, the data suggest that a more detail investigation of monoamine turnover should be carried out. The results are discussed in the light of the prevalent theories of audiogenic seizure susceptibility.


Includes bibliographical references.


vi, 72 pages




Northern Illinois University

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