James Fast

Publication Date


Document Type


First Advisor

Frampton, Elon W.

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Biological Sciences


Viruses; Interferon; RNA; Tumors


An investigation was made of the ability of polyriboinosinic-polyribocytidylic acid (Poly I:C), a synthetic double stranded RNA and inducer of interferon, to inhibit Finkel Biskis-Jinkins virus-induced osteosarcomas in CFl/Anl mice. Poly I:C affected both lifespan and average number of tumors per mouse when administered prophylactically — increasing the former and decreasing the latter. When Poly I:C was administered therapeutically to mice with established osteosarcomas, the effect was to prolong slightly the animals' lifespans, but tumors did not regress in size. Animals injected prophylactically with phosphate buffered saline (PBS), the diluent for the Poly I:C, showed a slight delay in their death rate indicating a possible interference with early viral replicative events. PBS was without apparent antiviral effect when administered therapeutically. The antiviral effects obtained with Poly I:C were accompanied by some negative consequences. When Poly I:C was administered in multiple doses the mice often developed severe diarrhea and bloating. Upon autopsy, many of these same mice exhibited extensive kidney and liver damage.


Includes bibliographical references.||Includes illustrations.


vi, 37 pages




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