Mittler, Sidney||Bennett, Jack (Cecil Jackson)
M.S. (Master of Science)
Department of Biology
The synthetic steroid Xorethynodrel was tested for its effect upon ring-shaped X and rod shaped Y chromosomes in Drosonhila melanogaster sperm. The XO method was used to detect "breakage of the X and the Y chromosome. A successive brood technique was used to determine differential breakage in the pre- and post-meiotic stages of spermatogenesis. Ten milligrams per milliliter of 5% sugar solution was used in a suspension as the test condition. The control was fed with 5% sugar solution. Two separate runs were done. Variation was found in the various analyses between the two runs. The first run produced more highly significant frequencies of induced non-disjunction (XO males and XXY females) than did the second run. There was considerable variation of sex ratios between the treated and control populations of Run I and Run II. More variation of sex ratios were observed in Run I. No increased production of sex mosaics was found. The wide variation between the two runs indicate that further work with the XO method is needed before any conclusive statements are made. The sex-linked recessive lethal test is discussed for possible further work in testing the mutagenic activity of Norethynodrel.
Grimwood, Brian Gene, "Norethynodrel and chromosome abberrations in Drosophila" (1967). Graduate Research Theses & Dissertations. 4134.
vii, 28 pages
Northern Illinois University
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