Publication Date


Document Type


First Advisor

Mittler, Sidney

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Biological Sciences


Drosophila melanogaster; Animal mutation; Gamma rays--Physiological effect; Heat--Physiological effect


The combined and separate treatments of hyperthermia and gamma radiation were used to determine the susceptibility of the w mus (1)106[^D]¹/sc⁸y⁺ B[^s] strain of Drosophila melanogaster to induced genetic aberrations. One day old males were subjected to treatments of 38°C for 1 hour, 1200 R, 38°C for 1 hour followed by 1200 R, or left untreated. Their progeny were scored for chromosome loss (X0) and nondisjunction (XXY), and dominant lethal (egg hatchability). Results showed no significant difference between the treatments in the induction of nondisjunction (XXY) events for all broods studied. No heat effect was observed in the induction of X0 males, but was observed for some broods in the dominant lethal study. Radiation was found to be mutagenic for all broods in both studies. A heat enhancement of radiation was noted for five of six broods in the dominant lethal study, but in only two of six broods in the chromosome loss study. It would appear that hyperthermic enhancement of radiation is more effective in the production of dominant lethals than the breakage or loss of a chromosome.


Includes bibliographical references.


vii, 36 pages




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