Publication Date

1980

Document Type

Dissertation/Thesis

First Advisor

Grosklags, James H.

Degree Name

M.S. (Master of Science)

Department

Department of Biological Sciences

LCSH

Antibiotics||Streptomyces||Fermentation

Abstract

There are many interactions between members of microbial populations. Some of these interactions are helpful to one or all of the members interacting, some have no effect, and some are detrimental. This study explores the possiblity of a protocooperative interaction between antibiotic-producing species of Streptomyces and the effect this interaction has in regard to antibiotic production. Species- of Streptomyces, all known to be weak producers of antibiotics, were cofermented in a mixed culture diffusion apparatus. The apparatus allowed mixing of the liquid media containing metabolites produced by two different species of Streptomyces while cell to cell contact was prevented. The culture filtrates were then assayed for antibiotic activity against a test regimen composed of pathogenic fungi and bacteria. It was noted that the process of cofermentation either inactivated existing antibiotic activity or caused the activity to go undetected in five of the six trials. One case of apparent synergism occurred in the cofermentation filtrate of Streptomyces lavendulae and Streptomyces viridochromogenes. Conjecture is made as to the reason for the results obtained and directions of further study are discussed.

Comments

Includes bibliographical references.

Extent

46 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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