Publication Date


Document Type


First Advisor

Grosklags, James H.

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Biological Sciences


Antibiotics; Streptomyces; Fermentation


There are many interactions between members of microbial populations. Some of these interactions are helpful to one or all of the members interacting, some have no effect, and some are detrimental. This study explores the possiblity of a protocooperative interaction between antibiotic-producing species of Streptomyces and the effect this interaction has in regard to antibiotic production. Species- of Streptomyces, all known to be weak producers of antibiotics, were cofermented in a mixed culture diffusion apparatus. The apparatus allowed mixing of the liquid media containing metabolites produced by two different species of Streptomyces while cell to cell contact was prevented. The culture filtrates were then assayed for antibiotic activity against a test regimen composed of pathogenic fungi and bacteria. It was noted that the process of cofermentation either inactivated existing antibiotic activity or caused the activity to go undetected in five of the six trials. One case of apparent synergism occurred in the cofermentation filtrate of Streptomyces lavendulae and Streptomyces viridochromogenes. Conjecture is made as to the reason for the results obtained and directions of further study are discussed.


Includes bibliographical references.


46 pages




Northern Illinois University

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