Kresheck, Gordon C.
M.S. (Master of Science)
Department of Chemistry
Micelles; Organophosphorus compounds
The characteristics of the mixed micelles formed from various mixtures of dimethyldecylphosphine oxide and dimyristoyl phosphatidylcholine in aqueous solution were studied. The mixed micelles molecular weights were determined from gel filtration studies using Sephadex G-50 and Sephacryl S-200 columns, sedimentation equilibrium studies and sedimentation velocity studies. The cmc for each mole fraction of the mixed micelles were determined from the calorimetric, dye binding and ³¹P NMR studies. The phase diagram was determined from the cloud point studies. The β parameters were calculated using the Sch'eraga-Mendelkern equation using the sedimentation coefficients from the sedimentation velocity experiments and intrinsic viscosities from the viscosity studies. The molecular weights were shown to increase as more DMPC was added. The molecular weight and viscosity studies implied that the shape of the mixed micelles at mole fractions 0.8 and 0.85 is probably ellipsoidal while at mole fraction 0.9 is most probably spherical. The cmc and the cloud points were observed to be decreased as more DMPC was added. Above the cp two distinct insoluble layers were formed upon standing. The top layer consists of DDPO rich mixed micelles and the bottom layer consists of DMPC rich mixed micelles.
Basri, Mahiran, "Characterization of the mixed micelles from various mixtures of dimethyldecylphosphine oxide and dimyristoyl phosphatidylcholine in aqueous solution" (1982). Graduate Research Theses & Dissertations. 1752.
vii, 71 pages
Northern Illinois University
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