Publication Date


Document Type


First Advisor

Majumdar, Pradip, 1954-

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Mechanical Engineering


Regional blood flow--Measurement--Computer simulation; Regional blood flow--Measurement--Mathematical models; Femoral artery; Mechanical engineering; Biomedical engineering


The pathological complications of atherosclerosis, namely heart disease and stroke, remain the leading cause of mortality in the world. Cardiovascular illness is highly prevalent among the American population. One manifesto of cardiovascular disease is Peripheral Artery Disease (PAD) which is caused by atherosclerosis in the arteries. Atherosclerosis is a vascular disease that reduces arterial lumen size through plaque deposition and arterial wall thickening. The flow patterns in the arteries are highly modulating along with the cardiac cycle and a strong function of the waveform created by the heartbeat. In this study, a computational simulation model is developed to analyze blood flow distribution in a femoral artery network based on Navier-Stokes equation. A comparative analysis of blood flow through femoral artery is done based on Newtonian and non-Newtonian blood flow by using Carreau-Yasuda model subjected to a waveform based on a cardiac cycle. The non-Newtonian CFD flow analysis model is use to analyze blood flow distributions in a femoral artery along with the adjacent capillary porous tissue medium. This simulation model is used to analyze the flow and stress field in a healthy and atherosclerosis affected femoral arteries. Velocity, pressure and Wall Shear Stress fields over cardiac cycle are analyzed to demonstrate that adverse flow field created upstream and downstream of the blockage that may cause enhanced growth in size of the blockage.


Advisors: Pradip Majumdar.||Committee members: Abhijit Gupta; Meung Kim.


79 pages




Northern Illinois University

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