Hess, Edwin A.||Lynch, Darrel L.||Feyerherm, Harvey A.
M.S. (Master of Science)
Department of Biological Sciences
Fructose and citrate concentrations in the semen of the rat ware found to be affected by beta-fluoropyruvate. This compound acts to inhibit the transfer of hydrogen ions between pyridine nucleotide coenzymes. Androgens have been shown to accelerate this hydrogen ion transfer system and in this respect this inhibitor was used as an androgen antagonist. The nature of the affect of beta-fluoropyruvate on the concentrations of fructose and citrate correlates with an androgen mediated pyridine transhydrogenation system coupled with the proposed pathway of Samuels, Harding and Mam (1962). This pathway was set forth as an explanation for the accumulation of these substances in semen.
Brown, Gerald A., "Certain effects of a metabolic inhibitor on the seminal vesicle-coagulating gland complex of the rat" (1967). Graduate Research Theses & Dissertations. 1709.
vii, 30 pages
Northern Illinois University
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