Lukaszuk, Judith M.
M.S. (Master of Science)
School of Family, Consumer and Nutrition Sciences
Nutrition; Proton pump inhibitors--Research; Gastric acid--Secretion--Research; Stomach--Secretions--Research; Vitamin B12--Nutritional aspects--Research
Background: Proton pump inhibitors (PPIs) affect gastric acid secretion. The use of PPIs in the elderly population (>70 years old) may increase the risk of vitamin B12 deficiency because gastric acid is needed for vitamin B12 digestion and absorption. However, it's unclear whether adults ages 50--70 years old that use PPIs chronically are at risk of vitamin B12 deficiency. Objective: To determine whether chronic use of PPIs results in increased urinary methylmalonic acid (uMMA) levels in adults ages 50--70 years old, indicating vitamin B12 deficiency. Methods: Fifteen men and women who had been taking PPIs daily for a minimum of one year were recruited. Fifteen subjects, not taking PPIs, were age-matched (+/- 3 years) and gender-matched to the subjects taking PPIs. Tissue stores of vitamin B12 were determined using uMMA. Results: There were no significant differences in uMMA levels between those taking PPIs (Mdn = 1.60 microg uMMA/mg creatinine), and those not taking PPIs (Mdn = 1.80 microg uMMA/mg creatinine) (p = 0.12). Conclusion: Chronic use of PPIs did not alter vitamin B 12 status of subjects in healthy adults ages 50-70 years old. Regular monitoring of vitamin B12 status does not appear to be needed in this age group, however, studies using larger groups are indicated to confirm these findings.
Warner, Tashia Sue, "Assessment of urinary methylmalonic acid levels in older adults on proton pump inhibitors" (2015). Graduate Research Theses & Dissertations. 1548.
Northern Illinois University
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