Publication Date

2015

Document Type

Dissertation/Thesis

First Advisor

Lukaszuk, Judith M.

Degree Name

M.S. (Master of Science)

Department

School of Family, Consumer and Nutrition Sciences

LCSH

Nutrition||Proton pump inhibitors--Research||Gastric acid--Secretion--Research||Stomach--Secretions--Research||Vitamin B12--Nutritional aspects--Research

Abstract

Background: Proton pump inhibitors (PPIs) affect gastric acid secretion. The use of PPIs in the elderly population (>70 years old) may increase the risk of vitamin B12 deficiency because gastric acid is needed for vitamin B12 digestion and absorption. However, it's unclear whether adults ages 50--70 years old that use PPIs chronically are at risk of vitamin B12 deficiency. Objective: To determine whether chronic use of PPIs results in increased urinary methylmalonic acid (uMMA) levels in adults ages 50--70 years old, indicating vitamin B12 deficiency. Methods: Fifteen men and women who had been taking PPIs daily for a minimum of one year were recruited. Fifteen subjects, not taking PPIs, were age-matched (+/- 3 years) and gender-matched to the subjects taking PPIs. Tissue stores of vitamin B12 were determined using uMMA. Results: There were no significant differences in uMMA levels between those taking PPIs (Mdn = 1.60 microg uMMA/mg creatinine), and those not taking PPIs (Mdn = 1.80 microg uMMA/mg creatinine) (p = 0.12). Conclusion: Chronic use of PPIs did not alter vitamin B 12 status of subjects in healthy adults ages 50-70 years old. Regular monitoring of vitamin B12 status does not appear to be needed in this age group, however, studies using larger groups are indicated to confirm these findings.

Comments

Advisors: Judith Lukaszuk.||Committee members: Masih Shokrani; Josephine Umoren.

Extent

105 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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