Publication Date


Document Type


First Advisor

Hess, Edwin A.||Feyerherm, Harvey A.||Lynch, Darrel L.

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Biological Sciences


Gonadotropin; Rats


Experiments were conducted on the binding properties of human chorionic gonadotropin (HCG) with rat serum proteins, and the effects of injections of HCG on levels of the individual fractions. During the HCG injection period, an additional serum fraction was detected in the area of the beta-2 globulins. The fraction disappeared after a 7-day withdrawal period from the treatment. It was considered that HCG could be bound at this location. Significant increases in concentration were also noted in each of the alpha-1, alpha-2, beta-1, and beta-2 globulins, as well as a concomitant decrease in albumin percentage. The greatest increase in the globulins occurred with the beta-2 fraction, while the gamma globulin concentration remained unchanged due to the treatment. These increases indicated a possible axis of HCG with physiological activity. The presence of biological activity of HCG during the treatment period was shown by significant increases in ovarian and uterine weights, compared with a group of untreated controls.


Includes bibliographical references.||Includes illustrations.


viii, 54 pages




Northern Illinois University

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