Author

Hae Gill Kim

Publication Date

1983

Document Type

Dissertation/Thesis

First Advisor

Kresheck, Gordon C.

Degree Name

M.S. (Master of Science)

Department

Department of Chemistry

LCSH

Liposomes||Surface active agents

Abstract

The interactions of phospholipid vesicles with nonionic surfactants in dilute aqueous solution were investigated. The physical properties of the mixed micelles formed from various mixtures of dimethyldecylphosphine oxide (DDPO) and dimyristoyl phosphatidylcholine (DHPC) in aqueous solution were studied by several methods. The CMC for each mole fraction of the mixed micelles was determined from ³¹P NMR and naphthalene solubilization studies. The enthalpy changes which accompany the heating of DMPC vesicles fused and treated with Triton X-100 were determined by differential scanning calorimetry. The fusion of vesicles prepared from several individual phospholipids was determined below and at the Tm in the presence of Triton X-100. Phospholipid mixtures at different molar ratios were examined to determine additivity of their tendency to undergo fusion.. The fusion products of DMPC vesicles with Triton X-100 and by themselves were observed by electron microscopy. The CMC of DDPO was observed to be decreased as more DMPC was added. The stability of small vesicles towards fusion increased as more DPPC was added. The enthalpy of melting for small vesicles was lower than that of multi1 ame11ar vesicles, while the enthalpy of melting for the fusion product was intermediate between that observed for single and multilame11ar vesicles.

Comments

Bibliography : pages 74-79.

Extent

viii, 79 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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