Hae Gill Kim

Publication Date


Document Type


First Advisor

Kresheck, Gordon C.

Degree Name

M.S. (Master of Science)

Legacy Department

Department of Chemistry


Liposomes; Surface active agents


The interactions of phospholipid vesicles with nonionic surfactants in dilute aqueous solution were investigated. The physical properties of the mixed micelles formed from various mixtures of dimethyldecylphosphine oxide (DDPO) and dimyristoyl phosphatidylcholine (DHPC) in aqueous solution were studied by several methods. The CMC for each mole fraction of the mixed micelles was determined from ³¹P NMR and naphthalene solubilization studies. The enthalpy changes which accompany the heating of DMPC vesicles fused and treated with Triton X-100 were determined by differential scanning calorimetry. The fusion of vesicles prepared from several individual phospholipids was determined below and at the Tm in the presence of Triton X-100. Phospholipid mixtures at different molar ratios were examined to determine additivity of their tendency to undergo fusion.. The fusion products of DMPC vesicles with Triton X-100 and by themselves were observed by electron microscopy. The CMC of DDPO was observed to be decreased as more DMPC was added. The stability of small vesicles towards fusion increased as more DPPC was added. The enthalpy of melting for small vesicles was lower than that of multi1 ame11ar vesicles, while the enthalpy of melting for the fusion product was intermediate between that observed for single and multilame11ar vesicles.


Bibliography : pages 74-79.


viii, 79 pages




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