A comparative study on the effects of Diabetes Mellitus and ethane-1-hydroxy-1, 1-diphosphonic acid on plasma cholesterol, plasma thyroxine and 3, 5, 3'-triiodothyronine in the rat
King, Sondra L.
M.S. (Master of Science)
Department of Human and Family Resources
Diabetes--Complications; Blood cholesterol; Thyroid hormones
The investigation was based on the hypothesis that both diabetes and treatment with EHDP inhibits 1 - αhydroxylase enzyme necessary for the conversion of 25-OH-D₂ to 1, 25 (0H)₂D₃ and lowering of 1, 25 (0H)₂D₃ may alter thyroid hormone levels. Plasma cholesterol was measured in both alloxan diabetic rates and Ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) treated rats; Plasma thyroxine (T₄) and 3, 5, 3'-triiodothyronine was measured in EHDP treated animals. Hypercholesterolemia resulted from untreated diabetes mellitus. Serum thyroxine levels were unaltered in EHDP treated groups and serum triiodothyronine levels were significantly higher in EHDP treated groups and serum triiodothyronine levels were significantly higher in EHDP treated group. No conclusions could be made from these results and more research is needed to further investigate the relationship between EHDP and thyroid hormone.
Kutty, Renuka, "A comparative study on the effects of Diabetes Mellitus and ethane-1-hydroxy-1, 1-diphosphonic acid on plasma cholesterol, plasma thyroxine and 3, 5, 3'-triiodothyronine in the rat" (1984). Graduate Research Theses & Dissertations. 134.
v, 34 pages
Northern Illinois University
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