Author

Renuka Kutty

Publication Date

1984

Document Type

Dissertation/Thesis

First Advisor

King, Sondra L.

Degree Name

M.S. (Master of Science)

Department

Department of Human and Family Resources

LCSH

Diabetes--Complications||Blood cholesterol||Thyroid hormones

Abstract

The investigation was based on the hypothesis that both diabetes and treatment with EHDP inhibits 1 - αhydroxylase enzyme necessary for the conversion of 25-OH-D₂ to 1, 25 (0H)₂D₃ and lowering of 1, 25 (0H)₂D₃ may alter thyroid hormone levels. Plasma cholesterol was measured in both alloxan diabetic rates and Ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) treated rats; Plasma thyroxine (T₄) and 3, 5, 3'-triiodothyronine was measured in EHDP treated animals. Hypercholesterolemia resulted from untreated diabetes mellitus. Serum thyroxine levels were unaltered in EHDP treated groups and serum triiodothyronine levels were significantly higher in EHDP treated groups and serum triiodothyronine levels were significantly higher in EHDP treated group. No conclusions could be made from these results and more research is needed to further investigate the relationship between EHDP and thyroid hormone.

Extent

v, 34 pages

Language

eng

Publisher

Northern Illinois University

Rights Statement

In Copyright

Rights Statement 2

NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.

Media Type

Text

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