Document Type

Article

Media Type

Text

Abstract

Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of nitric oxide on morphogenesis and secondary metabolism in fungi.

DOI

10.1128/AEM.00638-11

Publication Date

8-1-2011

Department

Department of Biological Sciences

ISSN

0099-2240

Language

eng

Publisher

American Society for Microbiology

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