Document Type
Article
Abstract
Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin production. Supplementation with a nitric oxide-releasing compound promoted cleistothecial formation and increased nsdD and steA expression, indicating that nitric oxide induces sexual development. This is the first study on the effect of nitric oxide on morphogenesis and secondary metabolism in fungi.
DOI
10.1128/AEM.00638-11
Publication Date
8-1-2011
Recommended Citation
Baidya S, Cary JW, Grayburn WS, Calvo AM. Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production. Appl. Environ. Microbiol. 2011 77:5524-8.
Original Citation
Baidya S, Cary JW, Grayburn WS, Calvo AM. Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production. Appl. Environ. Microbiol. 2011 77:5524-8.
Legacy Department
Department of Biological Sciences
ISSN
0099-2240
Language
eng
Publisher
American Society for Microbiology
